• Vitamin E protects against stress-induced gastric mucosal lesions in rats more effectively than vitamin C

藤田保健衛生大学医学部　太田好次

• ハプトグロビンの遺伝子多型は疾患罹患リスクおよびビタミンEの 疾患予防・治療効果を決定する重要な因子の一つである

エーザイ株式会社　ＣＪ部ビタミンＥ情報室　笠井俊二

• Kinetic Study of the Prooxidant Effect of a-Tocopherol. Hydrogen Abstraction from Lipids by a-Tocopheroxyl Radical

愛媛大学　大内綾

Vitamin E reduces cardiovascular disease in individuals with diabetes mellitus and the haptoglobin 2-2 genotype. S. Blum, M. Vardi‌, J. B. Brown, A. Russell, U. Milman, C. Shapira, N. S Levy,, R. Miller-Lotan, R. Asleh, and A. P. Levy, Pharmacogenomics, 11, 675-684 (2010).

High plasma levels of vitamin E forms and reduced Alzheimer's disease risk in advanced age. F. Mangialasche, M. Kivipelto, P. Mecocci, D. Rizzuto, K. Palmer, B. Winblad, L. Fratiglioni, J. Alzheimer Dis., 20, 1029-1037 (2010).

Alpha-tocopherol transfer protein disruption confers resistance to malarial infection in mice. M. S. Herbas, Y. Y. Ueta, C. Ichikawa, M. Chiba, K. Ishibashi, M. Shichiri, S. Fukumoto, N. Yokoyama, M. Takeya, X. Xuan, H. Arai, and H. Suzuki, Malar. J., 9:101 (2010).

Synthesis and characterization of BODIPY-α-tocopherol: A fluorescent form of vitamin E. R. West, C. Panagabko and J. Atkinson, J. Org. Chem., 75, 2883-2892 (2010).

a-TEA-induced death receptor dependent apoptosis involves activation of acid sphingomyelinase and elevated ceramide-enriched cell surface membranes. J. Li, W. Yu, R. Tiwary, S.-K. Park, A. Xiong, B. G Sanders, and K. Kline, Cancer Cell Int., 10:40 (2010).

a-TEA induces apoptosis of human breast cancer cells via activation of TRAIL/DR5 death receptor pathway. W. Yu, R. Tiwary, J. Li, S.-K. Park, L. Jia, A. Xiong, M. Simmons-Menchaca, Bob G. Sanders,1 and K. Kline, Mol. Carcinog. 49, 964-973 (2010).

a-Tocopherol adipose tissue stores are depleted after burn injury in pediatric patients. M. G Traber, S. W Leonard, D. L Traber, L. D Traber, J. Gallagher, G. Bobe, M. G Jeschke, C. C Finnerty, and D. Herndon, Am. J. Clin. Nutr., 92, 1378-1384 (2010).

Alpha-tocopherol quinone inhibits beta-amyloid aggregation and cytotoxicity, disaggregates preformed fibrils and decreases the production of reactive oxygen species, NO and inflammatory cytokines. S. Yang, W. Wang, T. Ling, Y. Feng, X. Du, X. Zhang, X. Sun, M. Zhao, D. Xue, Y. Yang, R. Liu, Neurochem. Int., 57, 914-922 (2010).

A nutrient approach to prostate cancer prevention: The Selenium and Vitamin E Cancer Prevention Trial (SELECT). B. K. Dunn, E. S. Richmond, L. M. Minasian, A. M. Ryan, L. G. Ford, Nutr. Cancer, 62, 896-918 (2010).

Modulation of gene expression by a-tocopherol and a-tocopheryl phosphate in THP-1 monocytes. J. Zingg, R. Libinaki, C. Lai, M. Meydani, R. Gianello, E. Ogru, A. Azzi, Free Radic. Biol. Med., 49, 1989-2000 (2010).

Plasma phospholipid transfer protein deficiency in mice is associated with a reduced thrombotic response to acute intravascular oxidative stress. C. Desrumaux, V. Deckert, S. Lemaire-Ewing, C. Mossiat, A. Athias, D. Vandroux, L. Dumont, S. Monier, J.-P. Pais de Barros, A. Klein, E. De Maistre, D. Blache, A. Beley, C. Marie, P. Garnier, L. Lagrost, Arterioscler. Thromb. Vasc. Biol., 30, 2452-2457 (2010).

Common variants of cytochrome P450 4F2 exhibit altered vitamin E-w-hydroxylase specific activity. S. A. Bardowell, D. E. Stec, and R. S. Parker, J. Nutr., 140, 1901-1906 (2010).

The value of tocotrienols in the prevention and treatment of cancer. P.W. Sylvester, A. Kaddoumi, S. Nazzal, and K. A. El Sayed, J. Am. Coll. Nutr., 2010, Jun 29 (3 Suppl.), 324S-333S. (Review)

Protective effects of vitamin E analogs against carbon tetrachloride-induced fatty liver in rats. R. Yachi, O. Igarashi, and C. Kiyose, J. Clin. Biochem. Nutr., 47, 148–154 (2010).

Hepatic α-tocopherol transfer protein: ligand-induced protection from proteasomal degradation. V. Thakur, S. Morley, and D. Manor, Biochemistry, 49, 9339-9244 (2010).

Tocopherol transfer protein sensitizes prostate cancer cells to vitamin E. S. Morley, V.Thakur, D. Danielpour, R. Parker, H. Arai, J. Atkinson, J. Barnholtz-Sloan, E. Klein, and D. Manor, J. Biol. Chem., 285, 35578–35589 (2010).

Cytoprotective effects of vitamin E homologues against glutamate-induced cell death in immature primary cortical neuron cultures: Tocopherols and tocotrienols exert similar effects by antioxidant function. Y. Saito, K. Nishio, Y. O. Akazawa, K. Yamanaka, A. Miyama, Y. Yoshida, N. Noguchi, and E. Niki, Free Radic. Biol. Med., 49, 1542-1549 (2010).

Regulation of xenobiotic metabolism, the only signaling function of a-tocopherol? M. G. Traber,Mol. Nutr. Food Res., 54, 661–668 (2010). (Review)

a-Tocopheryl phosphate – An active lipid mediator? J.-M. Zingg, M. Meydani, and A. Azzi,Mol. Nutr. Food Res., 54, 679–692 (2010). (Review)

Tocopheryl quinones and mitochondria. L. Gille, K. Staniek, T. Rosenau, J. C. Duvigneau, and A. V. Kozlov, Mol. Nutr. Food Res., 54, 601–615 (2010). (Review)

Vitamin E transport, membrane incorp metabolism: Is a-tocopherol in lipid rafts an oar in the lifeboat?S. Lemaire-Ewing, C. Desrumaux, D. Neel1, and L. Lagrost, Mol. Nutr. Food Res., 54, 631–640 (2010). (Review)

The location and behavior of a-tocopherol in membranes. J. Atkinson, T. Harroun, S. R. Wassall, W. Stillwell, and J. Katsaras, Mol. Nutr. Food Res., 54, 641–651 (2010). (Review)

In vitro inhibition of low density lipoprotein carbamylation by vitamins, as an ameliorating atherosclerotic risk in uremic patients. M. A. Ghaffari and M. Shanaki, Scand. J. Clin. Lab. Invest., 70, 122-127 (2010).

α-Tocopherol is an effective Phase II enzyme inducer: protective effects on acrolein-induced oxidative stress and mitochondrial dysfunction in human retinal pigment epithelial cells. Z. Feng, Z. Liu, X. Li, H. Jia, L. Sun, C. Tian, L. Jia, J. Liu, J. Nutr. Biochem., 21, 1222-1231 (2010).

Vitamin E status and metabolism in adult and aged aryl hydrocarbon receptor null mice. M. G. Traber, D. J. Mustacich, L. C. Sullivan, S. W. Leonard, A. Ahern-Rindell, N. Kerkvliet, J. Nutr. Biochem., 21, 1193-1199 (2010).

Vitamin E decreases endogenous cholesterol synthesis and apo-AI-mediated cholesterol secretion in Caco-2 cells. J.-F. Landrier, E. Gouranton, E. Reboul, N. Cardinault, C. El Yazidia, C. Malezet-Desmoulins, M. André, M. Nowicki, M. Souidi, P. Borel, J. Nutr. Biochem., 21, 1207-1213 (2010).

Vitamin E prevents steroid-induced osteonecrosis in rabbits. M. Kuribayashi, M. Fujioka, K. A. Takahashi, Y. Arai, M. Ishida, T. Goto, and T. Kubo, Acta Orthop., 81, 154–160 (2010).

Beneficial effects of vitamin E isomer supplementation on static and dynamic bone histomorphometry parameters in normal male rats. M. Z. Mehat, A. N. Shuid, N. Mohamed, N. Muhammad, I. N. Soelaiman, J. Bone Miner. Metab., 28, 503–509 (2010).

a-Tocopherol administration produces an antidepressant-like effect in predictive animal models of depression. K. R. Lobato, C. C. Cardoso, R. W. Binfare, J. Budni, C. L.R. Wagner, P. S. Brocardo, L. F. de Souza, C. Brocardo, S. Flesch, A. E. Freitas, A. L. Dafre, A. L. S. Rodrigues, Behav. Brain Res., 209, 249-259 (2010).

Metals, oxidative stress and neurodegenerative disorders. K. Jomova, D. Vondrakova, M. Lawson, and M. Valko, Mol. Cell. Biochem., 345, 91–104 (2010).